C1GALT1C1 and colorectal cancer: Here, astoundingly, we found that the over-expressed genes in high-ELF4 tumours of PAAD, KIRC, BRCA and LUAD tumours were all enriched for, pathways associated with 1) Defective C1GALT1C1 causes Tn polyagglutination syndrome, 2) Defective GALNT12 causes colorectal cancer 3), Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis, 4) O-linked glycosylation of mucins Homo sapiens, 5) Termination of O-glycan biosynthesis (Fig 5C–5F, also see S4 File).