INS and Insulin resistance: Overexpression of Lpl encoding lipoproteinlipasein the liver of mice led to a 2-fold increase in hepatic triglyceridecontent and caused insulin resistance partly due to the impaired responseto insulin to suppress endogenous glucose production.33 In this study, a high level of Lpl inthe ZDF rats was downregulated by both L-NAAB and H-NAAB, which maylead to improved insulin sensitivity.