In this paper, Donnelly et al. from Ru-Rong Ji's lab report that activation of the STING (stimulator of interferon genes) signaling mechanism in nociceptive primary sensory neurons functions in an analgesic manner in naive and injured mice, using STING agonists, and applying sophisticated pain behavioral metrics to uninjured mice and mice with nerve constriction injury or a rigorous model of bone cancer pain. Here, STING1 is linked to bone cancer.