CD4 and neoplasm: (1) The high-risk group had more complex immune cell components than the low-risk group, including cells executing anti-tumor reactivity (activated CD4 T cells, activated dendritic cells, central memory CD4 T cells, central memory CD8 T cells, Natural killer cells and Natural killer T cells) and cells delivering pro-tumor suppression (immature dendritic cells, MDSCs, plasmacytoid dendritic cell, regulatory T cells and Type 2 T helper cell) (Figure 7B).