Many factors may be involved in this crosstalk, including genetics, changes in vitamin D and parathyroid hormone (PTH) levels, aging, increased levels of systemic and local inflammatory markers (ie, interleukin-6 [IL-6] and tumor necrosis factor), obesity and adipokines, mechanical loading, and altered hormones (ie, osteocalcin, resistin, and myostatin) [7,8]. The gene discussed is IL6; the disease is Obesity.