Our results from DFV-B infection indicated that EMT CD4+ T cells were less permissive to infection, but once infected were much more likely to establish latency (Figure 3E and F), which supports that EMT CD4+ T cells are the primary targets for latent infection, and highlights the feasibility of our DFV-B system. The gene discussed is CD4; the disease is disease arising from reactivation of latent virus.