ESR1 and early-onset autosomal dominant Alzheimer disease: For example, single nucleotide polymorphism in or near ADCYAP receptor type I (ADCYAP1R1), NPS receptor (NPSR1), estrogen receptor 1 (ESR1), SRSF protein kinase 2 (SRPK2) genes have been associated with autism spectrum disorders, Alzheimer’s disease behavioral traits, anxiety, impulsivity and attention deficit-related traits [21, 54–59].