Given the diagnosis of PAH, the KCNK3 (OMIM 603220), KCNA5 (OMIM 176267), CAV1 (OMIM: 601047), BMPR2, SMAD4, ENG, and ACVRL1 genes were also sequenced, with no pathogenic or suspicious variant detected. Here, SMAD4 is linked to pulmonary arterial hypertension.