Clinical manifestations of APS fall under a wide spectrum including asymptomatic carrier patients with aPL positivity, classical APS with vascular thrombosis and/or fetal losses, aPL positivity without thrombotic APS findings (i.e., thrombocytopenia, hemolytic anemia, livedo reticularis, and seizures), or catastrophic APS characterized by multi-organ failure due to multiple microthrombosis [1, 4, 5]. This evidence concerns the gene FASLG and Livedo reticularis.