MAPK1 and cancer: Three maps—Adaptive Immunity, Innate Immunity and Cancer-Associated Fibroblasts—contain the same canonical representation of the cascade (Figure 1A); the Cell Survival map includes both the canonical (generally accepted and repeated in different databases) representation of MEK and ERK activation as well as their spatial regulation by SEF/IL17RD [14, 23] (Figure 1C) and KSR1 scaffold mechanism via BRAF (Supplementary Figure S1), and the epithelial-mesenchymal transition (EMT) and Senescence map has the canonical pathway together with details of the RAF1 phosphorylation events (Figure 1D).