In this study, relevant keywords including “diabetes”, “diabetes mellitus”, “adverse drug reaction”, “toxicity”, “pharmacokinetics”, “toxicokinetic”, “pharmacodynamic”, “mechanism”, “statin”, “HMG-CoA reductase inhibitor”, “dyslipidemia”, and “hyperlipidemia” were searched in the Web of Science, MEDLINE (PubMed), Scopus, and Google Scholar to retrieve articles that examined the effects of diabetes on the pharmacokinetics, pharmacodynamics, and side effects of different types of statins. The gene discussed is HMGCR; the disease is diabetes mellitus.