SIRT1 and Alzheimer disease: In the rat brain, activation of Sirt-1 inhibited p53 acetylation and ROS production, which was further promoted by the addition of EX527, a Sirt-1 inhibition, which indicated that Sirt-1 might exert a protective effect against oxidative stress-related AD, by deacetylating p53 and thus scavenged ROS accumulation [23].