This study is testing a combination of a therapeutic HPV vaccine together with tumor-targeted IL-12 as “cold” to “hot” tumor converter (Strauss et al., 2019), and a bi-functional fusion protein blocking PD-L1 and TGFβ (Strauss et al., 2018) which has demonstrated enhanced efficacy in preclinical models of HPV-associated disease (Rumfield et al., 2020). Here, CD274 is linked to neoplasm.