In addition to classical tumor-promoting TGFB family and IL1 family genes, immune checkpoints CD73 (NT5E) and TWEAK-R (TNFRSF12A) were identified as immune suppressive genes for which high expression was associated with a decreased survival probability, suggesting that these molecules might be targets for immunotherapy for subjects with this CESC phenotype. Here, IL1B is linked to cervical squamous cell carcinoma.