The “altered” phenotypes can be further divided into “altered-excluded” and “altered-immunosuppressed.” The former describes tumors containing immune cells in the tumor margin, but not within the tumor bed, and the latter describes tumors containing an overall intermediate “Immunoscore” (defined by CD3 and CD8 immunohistochemistry) while also expressing immune-suppressive molecules such as TGFβ and inhibitory immune checkpoint genes. This evidence concerns the gene TGFB1 and neoplasm.