In patients with obesity, a dysregulation of adipocytokines is known to occur with overproduction of pro-inflammatory adipocytokines such as leptin, visfatin, resistin, and interleukin-6 and decreased production of anti-inflammatory adipocytokines with insulin-sensitizing properties such as adiponectin and omentin. Here, NAMPT is linked to obesity due to melanocortin 4 receptor deficiency.