FMR1 and cerebellar ataxia: FMR1 gene premutation is the first single-gene cause of primary ovarian failure (Fragile X-associated primary ovarian insufficiency) and one of the most common causes of ataxia (fragile X-associated tremor/ataxia syndrome), and multiple additional phenotypes including neuropathy and neuropsychiatric alterations (Mila et al., 2018).