Moreover, the upregulated genes by Tet1 deficiency were enriched in homologous recombination, cell cycle, fanconi anemia pathway, Alzheimer’s disease, and metabolic pathways, while downregulated genes enriched in Ras signaling pathway, neurotrophin signaling pathway, which can cause premature ovarian failure (Dorfman et al., 2014), and notably autophagy and ubiquitin mediated proteolysis (Figures 2D–F). This evidence concerns the gene BDNF and early-onset autosomal dominant Alzheimer disease.