ITGB1 and ovarian neoplasm: As previously mentioned that ITGB1 is upregulated in OC and promotes ovarian tumor growth and progression (Yang et al., 2014), ITGB1 can upregulate STAT1 through activating focal adhesion kinase (FAK), the downstream kinase of ITGB1, leading to the upregulation of MMP-2 and MMP-9.