Among microenvironment–cell interaction-mediated regulation of ABCB1, a family of ECM proteins called CCN (CYR61/CTGF/NOV) was demonstrated to regulate ABCB1 and to confer vinblastine resistance in renal cell carcinoma cells targeting αv β3 (Long et al., 2013). The gene discussed is CCN1; the disease is renal cell carcinoma.