Among microenvironment–cell interaction-mediated regulation of ABCB1, a family of ECM proteins called CCN (CYR61/CTGF/NOV) was demonstrated to regulate ABCB1 and to confer vinblastine resistance in renal cell carcinoma cells targeting αv β3 (Long et al., 2013). Here, ABCB1 is linked to hereditary clear cell renal cell carcinoma.