Among microenvironment–cell interaction-mediated regulation of ABCB1, a family of ECM proteins called CCN (CYR61/CTGF/NOV) was demonstrated to regulate ABCB1 and to confer vinblastine resistance in renal cell carcinoma cells targeting αv β3 (Long et al., 2013). This evidence concerns the gene ABCB1 and renal cell carcinoma.