TLR4 and viral infectious disease: Rel1, Rel2, Dicer2, and STAT are the key factors in the Toll, Imd, RNAi, and JAK-STAT pathways, respectively (Bian et al., 2005; Antonova et al., 2009; Lambrechts et al., 2013; Kumar et al., 2018; Cabral et al., 2020), and these factors have shown effectiveness against viral infections in some mosquito species (Fragkoudis et al., 2008; Xi et al., 2008; Paradkar et al., 2012; Lambrechts et al., 2013; Angleró-Rodríguez et al., 2017).