CASP3 and melanoma: Similarly, circulating miR-194 negatively regulated phosphorylated AKT protein levels through PI3K and suppressed the PI3K/AKT/FOXO3a pathway, leading to increased cell apoptosis through p53/p21 signaling, resulting in increased levels of Caspase 3/9, p21, and p53 proteins in melanoma cells (57).