HIF1A and colorectal cancer: Intriguingly, primary tumor hypoxia status was positively associated with MDSC fraction of pre-metastatic liver (mouse model: Spearman test, r = 0.817, p = 0.011; Figure 5C), while the same correlation was observed in both GSE49355 and GSE14297 datasets containing patients with colorectal cancer liver metastasis, which indicated that hypoxia condition of primary tumor might trigger the metastasis process to target liver via HIF-1 signaling (GSE49355: Spearman test, r = 0.681, p = 0.012; GSE14297: Spearman test, r = 0.459, p = 0.056, Figures 5D,E).