According to studies, there is a negative correlation between VEGF expression and cancer cell radiosensitivity, and the inhibition of VEGF expression promotes radiosensitivity of esophageal cancer cells, while the administration of fenofibrate can effectively diminish hypoxia-induced VEGF secretion in MCF-7 cells, a mechanism whose association with PPAR-α expression level remains unidentified. The gene discussed is PPARA; the disease is cancer.