PPARA and colorectal cancer: With regard to its powerful oxidative property, contrary to the aforementioned anti-tumorigenesis effect with excessive oxidative stress on cancer cell mitochondria, other scientists argued that the inhibition of PPAR-α has yielded anti-proliferative effect on human paraganglioma, pancreatic and colorectal cancer cells in vitro with decreased antioxidant capacity and carnitine palmitoyl transferase-1A pattern expression (49–52).