PPARA and colorectal carcinoma: In colorectal carcinoma SW620 cells which express low levels of PPAR-α mRNA, two PPAR-α agonists, LY171883, and WY14643 attenuate early stages of colon tumorigenesis by diminishing AP-1-mediated transcriptional activation of genes involving inflammatory response like Cox-2 and VEGF via PPRE-driven transcription in a PPAR-α-dependent fashion (82).