TNFSF10 and central nervous system cancer: Moreover, the research team has also revealed the mechanisms of sensitization of TRAIL-induced apoptosis by MK886: it was found that MK886 reduced the expression of an antiapoptotic protein, namely survivin, which is related to tumor cell resistance to TRAIL, and MK886 activates p38 mitogen-activated protein kinase (MAPK) pathway, leading to the overexpression of the death receptor 5 (DR5), eventually causing intensive apoptosis in glioma cells (90).