A study has investigated the anticancer activities of fenofibrate on the invasion and migration of human oral cancer Cal27 cells, which is associated with the attenuation of MMPs expression, enhancement of AMPK phosphorylation, and suppression of NF-κB p65 and its DNA binding activity, while such effect was observed to present in a AMPK-dependent manner, rather than PPARα signaling (68). The gene discussed is PPARA; the disease is lip and oral cavity carcinoma.