The same research team has also found that in oral cancer mouse model, the expression level of PPAR-α protein was negatively correlated to cancer advancement; and the activation of PPAR-α by fenofibrate induced decreased migration ability in oral cancer cells in vitro, assumably via reprogramming ATP pathway, interfering with the characteristic Warburg effect of cancer cells (69). Here, PPARA is linked to lip and oral cavity carcinoma.