A study has detected the effects of fenofibrate in two settings: in a PPAR-α-independent manner, the unprocessed fenofibrate represses mitochondrial respiration; and in a PPAR-α-dependent manner, fenofibric acid converted by blood and tissue esterases stimulate glioblastoma cells to switch from glycolysis to FAO. This evidence concerns the gene PPARA and glioblastoma.