Considering that PPAR-α is a candidate treatment for several types of cancer, a study has analyzed the expression of PPAR-α nuclear receptor in HNPGLs and assessed the functions of two PPAR-α modulators: PPAR-α agonist (WY14643) and PPAR-α antagonist (GW6471) in a unique model of HNPGLs cells, where the protein expression level of PPAR-α is remarkably high. This evidence concerns the gene PPARA and cancer.