In summary, we can highlight the relevance of chaperones belonging to the HSP70 and HSP60 families, some of which have been already described by other studies as deregulated in the tumor plasma cells of patients with MM, contributing to disease progression by maintaining protein homeostasis, blocking apoptosis and helping in the stabilization of oncoproteins (44). The gene discussed is HSPD1; the disease is Miyoshi myopathy.