METH abuse has prominent CNS side effects such as psychosis and depression.28,29 Alavijeh et al. (2019) showed that METH consumption induced anxiety-like behaviors via modulation of oxytocin receptors in methamphetamine addicted rats the same as our finding.30 These behavioral changes can also be due to the high and quick distribution of METH in the body and enhancement of synaptic and extra-synaptic levels of serotonin, noradrenaline and dopamine.31 This evidence concerns the gene OXTR and major depressive disorder.