We observed a significant differences in mortalin levels between exosomes derived from healthy people and cancer patients (p < 0.001 for hepatocellular carcinoma patients, p < 0.00001 for gastric carcinoma patients, p < 0.00001 for Breast cancer patients, p < 0.0001 for colon cancer patients, p < 0.0001 for ovarian cancer patients, p < 0.001 for and p < 0.001 for prostate cancer patients). Here, HSPA9 is linked to malignant colon neoplasm.