Importantly, molecular docking results showed the molecular docking relationship with LibDock Score value between 90 and 150 points accounted for 80 pairs (75.00%) and also confirmed that the target genes PTAFR, CNR1, CNR2, FDFT1, and HSP90AA1 could better combine with most sesquiterpene pyridine alkaloids through the binding interactions between amino acid residues and pyridine rings and were mainly focused on NLRP3 inflammasome activation, IL1B and IL18 secretion, progression of type-2 diabetes, enzymes of the sterol biosynthesis pathway, and drug resistance [42–44]. This evidence concerns the gene PTAFR and type 2 diabetes mellitus.