TP53 and cancer: Furthermore, the LSD1 upregulation affected the cell cycle of cancer [10] which can result in the inhibition of the p53 tasked to inhibit the reaction between TP53BP1 and p53, thus p53 binding protein 1 [11], which then enhances the growth of cancer, invasion, and metastasis by affecting the methylation/demethylation process [7, 12, 13].