However, LSD1 has also been shown to be understated in more differentiated AML subtypes such as the M3 FAB subtype and acute promyelocytic leukemia; still, experiments using small molecules propose that LSD1 still has a vital role in controlling AML cell differentiation even in cells that are not strictly reliant on LSD1 for survival. The gene discussed is KDM1A; the disease is acute promyelocytic leukemia.