NOTCH1 and acute lymphoblastic leukemia: For lymphoid leukemias, Yatim et al. [79] and Lobry et al. [80] stated that T-cell acute lymphoblastic leukemia (T-ALL) caused by the malignant change of T-cell progenitors, mutations in Notch1, foremost to aberrant and constitutively vigorous Notch1 signaling, add to oncogenic transformation and are hallmarks of this ailment.