Li R. et al. (2018) reported that SIRT3 upregulated the expression of Foxo3a, inhibiting epithelial–mesenchymal transition (EMT) in PCa cells by attenuating the Wnt/β-catenin signaling pathway. Similarly, Shen also declared that the silencing of circ-Foxo3 promoted tumorigenesis and resistance to drugs, especially docetaxel, by enhancing EMT. Both the circ-Foxo3/Foxo3/EMT axis and SIRT3/Wnt/β-catenin/Foxo3A are promising prognostic and therapeutic targets for PCa patients. However, a study carried by Kong et al. (2020) showed a converse perspective about the function of circ-Foxo3. The gene discussed is SIRT3; the disease is posterior cortical atrophy.