In light of the circRNA-miRNA-mRNA network, bioinformatics analysis revealed that circ-Foxo3 upregulates the expression of USP44, promoting the progression of GC, and sponges miR-143-3p, and the results were validated by RNA-binding protein immunoprecipitation (RIP) assay, dual-luciferase reporter assay, and RNA pull-down assay (Fang et al., 2019; Ouyang et al., 2019; Wang Z. et al., 2019). This evidence concerns the gene USP44 and gastric cancer.