However, circ-Foxo3 exerts a different role in GC, PCa and GBM—it promotes tumor progression via the circ-Foxo3/miR-143-3p/mRNA USP44, circ-Foxo3/miR-29a-3p/mRNA SLC25A15, and circ-Foxo3/miR-138-5p/432-5p/mRNA NFAT5 axes (Zhang et al., 2019; Kong et al., 2020; Xiang et al., 2020). This evidence concerns the gene FOXO3 and neoplasm.