When we further evaluated the association between CCN3 expression and prognosis in pan-cancer, we found that high CCN3 expression was associated with shorter OS in seven types of cancer (ACC, BLCA, GBM, LAML, MESO, STAD, and uveal melanoma) and longer OS in two types of cancer (CHOL and KIRC, Figure 3C). Here, CCN3 is linked to bladder transitional cell carcinoma.