Overexpression of CCN2 also has been shown to induce the upregulation expression of Wnt/β-catenin transcriptional target genes, and our group also proved CCN2 was associated with the Wnt signaling activation in hepatocellular carcinoma (HCC) (Jia S. et al., 2017). This evidence concerns the gene CCN2 and hepatocellular carcinoma.