TNF and rheumatoid arthritis: An inflammatory profile was also demonstrated in the serum of RA patients, including over-expression of a number of interleukins (IL-1β,−1RA,−2,−4,−5,−6,−8,−12,−13,−15 and−17) (Figure 1B), cytokines, chemokines and growth factors (Eotaxin, FGFbasic, GCSF, GM-CSF, IFNγ, MCP-1, MIP-1α, PDGF-BB, TNFα, and VEGF) (Figure 1C).