Based on double-blinded, placebo-controlled, randomised, clinical trials that confirmed its safety and efficacy, the mTOR-inhibitor everolimus (Votubia®) was approved in Europe in 2011 for the treatment of subependymal giant cell astrocytoma (SEGA) and renal angiomyolipoma (5–13). Here, MTOR is linked to subependymal giant cell astrocytoma.