Impairment of the release of gastro-protective factors such as cyclooxygenase COX, PGE2, bicarbonate, and mucus in addition to increased gastric acid secretion, free radical formation, and excessive generation of inflammatory mediators, e.g., TNF-α, are suggested to be the underlying pathogenic mechanisms of IND-induced gastric ulcers (Abbas and Sakr, 2013). The gene discussed is TNF; the disease is gastric ulcer.