INS and diabetes mellitus: Investigating the collective activity of beta cell populations is gaining attention, primarily because of the increasing amount of data showing that the pathogenesis of diabetes comprises disruptions of regulated collective cellular activity and the consequent disturbance in insulin secretion (Head et al., 2012; Hodson et al., 2013; Skelin Klemen et al., 2017; Westacott et al., 2017a; Adams et al., 2020; Akalestou et al., 2020).