The observed low hepatic expression of Lrp-1 in SHRs and the subsequent downregulation by high physical activity increases the risk of steatosis and insulin resistance but also that of Alzheimer Disease as brain and hepatic expressed Lrp-1s are part of clearance of misfolded amyloid β oligomers (Sagare et al., 2012; Khodadadi et al., 2018). Here, LRP1 is linked to Alzheimer disease.