In summary, a down-regulation of UCP-3 in the M. soleus and an induction of GLUT-1 in the M. gastrocnemius are common adaptations to exercise in both strains, whereas an induction of the muscular expression of PCSK9 in normotensive rats and a reduction of hepatic expression of oxLDL receptor (LOX) and LRP-1 in SHRs are strain specific differences that are associated with hypertension. The gene discussed is LRP1; the disease is hypertensive disorder.