In another study, Youn et al. (2018) found that the levels of LC3B, Beclin1, and LAMP-2 were higher in the CSF of PD patients, which means that CSF levels of some autophagy-related proteins might represent potential diagnostic and prognostic biomarkers of early-stage PD in patients (Youn et al., 2018). This evidence concerns the gene LAMP2 and Parkinson disease.