PI3 and Autoimmunity: FGF family uses Ras/MAPK, PI3, and PLCγ pathways (Diez Del Corral and Morales, 2017), through which it helps for neuroprotection, cell survival, and neural differentiation during embryonic development, it is also linked with epileptogenesis, mood disorders and autoimmunity in the brain (Turner et al., 2016).