This body of research, illustrating the interaction of PRMTs with key spliceosome components, in conjunction with that illustrating pathological interaction of polyGR and polyPR DRPs (Figure 5B) with these same spliceosome components to decrease splicing fidelity, raises important questions about the interaction of these two phenomena in C9-ALS. The gene discussed is C9; the disease is amyotrophic lateral sclerosis.