APP and Alzheimer disease: A study by Lecca et al. (2019) investigated the effects of PHEN (5 mg/kg) in mitigating apoptosis and neuroinflammation in both wild-type (WT) and amyloid-precursor protein (APP)/presenilin 1 (PSEN1) expressing AD mice (APP/PS1 mice) when exposed to mild TBI (mTBI).