Additionally, in the last decades, many publications have implicated miRNA in the role of AD disease progression, particularly in 3′-UTR dysregulation of targeted mRNAs of APP, PSEN1, PSEN2, and APOE4 genes (Avila, 2006; Vilardo et al., 2010; Dickson et al., 2013; Liu, Song et al., 2014; Santa-Maria et al., 2015; Reddy et al., 2016). This evidence concerns the gene APP and Alzheimer disease.