Conversely, although many SNPs in the IL7R gene, which was detected with GWAS but not RHM, have been found to be associated with PBC and other autoimmune diseases, it appears that they are all linked to a single locus, rs6897932 (chr5:g.35874575C > T), known to affect the inclusion of exon 6 through splicing regulation. The gene discussed is IL7R; the disease is autoimmune disease.