On the other hand, our GWAS analysis identified two loci that are already known PBC QTLs in the Japanese population, namely IL7R (rs7717955 (chr5:g.35862841C > T); P = 3.91 × 10−8) and CD80/POGLUT1 (rs13092998 (chr3:g.119245044G > T); P = 2.57 × 10−10) [19, 46], but that were not detected by using the RHM method. Here, IL7R is linked to primary biliary cholangitis.