CD33 and acute myeloid leukemia: We initiated a single-center, single-arm, Phase I clinical trial (NCT03126864) to investigate the feasibility and safety of autologous T cells, modified to express a CD33-targeted CAR with 4-1BB and CD3ζ endo-domains and co-expressed with truncated human epidermal growth factor receptor (HER1t) [8], in patients with relapsed/refractory AML.