A significant difference in PD-1.5 allelic and genotype frequencies was observed between HCC and LC patients [PD-1.5 Allele T OR = 1.6 (1.13–2.1), padj = 0.006; PD-1.5 genotype TT co-dominant model: OR = 4.4 (1.2–15.6), padj = 0.016; dominant model: OR = 1.6 (1.1–2.35), padj = 0.013; recessive model: OR = 3.7 (1.1–13.1), padj = 0.02]. This evidence concerns the gene PDCD1 and hepatocellular carcinoma.