The PD-1.9 homozygous genotype TT was observed frequently among patients with LC, HCC and LC + HCC groups compared to CHB patients in the co-dominant [LC vs. CHB: OR = 3.8(1.8–8.0), padj = 0.0007; HCC vs. CHB: OR = 2.1(1.01–4.3), padj = 0.047; LC + HCC vs. CHB: OR = 2.9(1.5–5.6), padj = 0.004] and recessive [LC vs. CHB: OR = 3.4(1.7–6.7), padj = 0.00019; HCC vs. CHB: OR = 1.8(1.09–3.6), padj = 0.042; LC + HCC vs. CHB: OR = 2.5(1.4–4.7), padj = 0.0015] models respectively. This evidence concerns the gene PDCD1 and hepatocellular carcinoma.