Finally, some forms of insulinomas, endocrine pancreatic tumours that lead to severe forms of hyperinsulinemic hypoglycaemia, associated hypermethylation at the IGF2 differentially methylated region 2 (IGF2-DMR2), with IGF2 loss-of-imprinting and overexpression56. This evidence concerns the gene IGF2 and pancreatic neuroendocrine tumor.