In our previous study, we showed that the aHSG/fetuin-A plasma levels and the Ahsg mRNA expression in the liver were lower in rats after bariatric surgery, even though the study included animals with diet-induced obesity and studied effects of different bariatric procedure: duodenal-jejunal omega switch (DJOS)15. Here, AHSG is linked to obesity due to melanocortin 4 receptor deficiency.