VDR and hypercalcemia disease: Inappropriate interaction with the VDR can then mediate pathologic intestinal calcium reabsorption and mobilization from bone3, resulting in hypercalcemia and gastro-intestinal (nausea, vomiting, constipation, polydipsia), neurological (confusion, depression, hallucination, coma), cardiac (QT shortening, ST-segment elevation, bradyarrythmias), or renal (polyuria, nephrocalcinosis, acute kidney injury) symptoms.