In this study, it was shown that the TAZ gene increased VDR and decreased p53 expression by decreasing the tumor cell susceptibility to vitamin D. Vitamin D could effectively down-regulate the expression of VDR and TAZ, and up-regulate the p53 expression, which might result in inhibiting cell proliferation of ICC and worsening or spreading the disease25. The gene discussed is VDR; the disease is intrahepatic cholangiocarcinoma.