In women, APOE e4+/+ status (β = − 0.78, 95% CI − 1.56 to − 0.01, p = 0.05), stroke (β = − 0.092, 95% CI − 1.83 to − 0.01, p = 0.05) and hypertension (β = − 0.48, 95% CI 0.87 to − 0.09, p = 0.02) were associated with memory decline. The gene discussed is APOE; the disease is Stroke.