We showed that two gene networks, including a CLOCK-dependent circadian network, are positively correlated with NREM delta power in a population of (C57BL/6J × 129S1/SvImJ) F2 mice and negatively correlated with tauopathy—estimated by neuropathologic measures of the Braak score and neurofibrillary tangle density—in a human AD population modeling AD progression. Here, CLOCK is linked to tauopathy.