We use data from two extensive public resources, a human Alzheimer’s disease cohort from the Mount Sinai Brain Bank (N = 125) reflecting AD progression41 and a (C57BL/6J × 129S1/SvImJ) F2 mouse population in which NREM delta power was measured (N = 98)42, to test the hypothesis that specific gene networks in the prefrontal cortex are associated with both NREM sleep and AD-related tau pathology. The gene discussed is MAPT; the disease is Alzheimer disease.