CASP3 and neoplasm: Furthermore, Flag-E47-expressing tumors exhibited significant increased Ki67+ cells and decreased cleaved caspase-3 + (CC3 + ) cells, all of which were rescued by silencing of ΔNp63α (Fig. 2I), indicating that E47-mediated upregulation of ΔNp63α consequently facilitates tumor growth through increased cell proliferation and reduced apoptotic cell death.