Using the phenotype of primary TAMs as a reference,19 we found that CM from KRAS mutant lines, but not CM from KRAS wild-type lines, actively reprogramed macrophages to a TAM-like phenotype with a CD206high/HLA-DRlow expression, a stretched and elongated morphology, and increased production of tumor-supportive cytokines (Fig. 2a, c). Here, KRAS is linked to neoplasm.