APOE and Alzheimer disease: Moreover, AAO in group of ‘APOE X/X + CC (C677T) + AA (A1298C)’ in AD patients was higher than group of ‘APOE 4/X + 4/4 + TT (C677T)’ or group of ‘APOE 4/X + 4/4 + CC (A1298C)’ (higher by 5.3 years and 2.9 years, separately).